Silhueta de pessoa indiferenciada

Leonor Cancela

Professor catedrático
Centro de Ciências do Mar
Subsistema
Orgãos de Gestão
Unidade ID
Centro de Ciências do Mar
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado
Leonor Cancela /LC is Full Professor at the Faculty of Medicine and Biomedical Sciences of the University of Algarve/UALG, member of the Algarve Biomedical Centre and founding member of the Centre for Marine Sciences /CCMAR. - She developed her undergraduate/graduate studies at University Paris VI- Pierre et Marie Curie and her PhD work at INSERM/ Hospital Lariboisière, in Paris where she was awarded her PhD in 1985 with honors. She was hired as a postdoctoral researcher by the Univ. of California between Jan 1986-Jan 1988 at the UC Riverside campus and between Feb1988- Nov1992 at the UC San Diego campus. She obtained a position at UALG in Dec1992 and became full professor in 2006. - She was elected President of the Portuguese Biochemical Society between 2005-2008 and is member of the board of the Portuguese Society of Genetics since 2010, elected as President in January 2020 to present. - She is Director of the Bachelor and PhD programs in Biomedical Sciences of the UALG since their implementation, Director of the UALG Doctoral College by rector nomination since 2019 and held several academic positions including director of the Department of Biomedical Sciences and Medicine and President of the Pedagogic and Scientific councils for several terms. - - She is currently President of the Scientific Council of the newly created Faculty of Medicine and Biomedical Sciences of the University of Algarve. - She implemented in 1994 the BIOSKEL research laboratory that she leads since then (http://bioskel.ccmar.ualg.pt) and has coordinated over 150 undergraduate, PhDs and postdoctoral fellows, published over 200 articles in international journals, 15 book chapters, and is co-author of 7 patents and 3 registered marks. - She has implemented in 2008 the Lab.it project to provide hands-on training in molecular biology to high school students and teachers and contribute to disseminate information on the use of molecular tools to different society applications. - She is the co-founder of Technozeb, a Business Unit of Technophage SA involved in the discovery of molecules with therapeutic interest using zebrafish. - She is regularly invited to give seminars and integrate academic juris and evaluation panels in national/international institutions and agencies, including chair of ERC committees. - Research interests focus in molecular, environmental and epigenetic determinants of skeletogenesis in health and disease and the use of zebrafish as model for human pathologies with skeletal phenotypes. - LC participated in the development of several in vitro cell systems and in vivo assays that were used to uncover cellular and molecular mechanisms of bone formation and regeneration but also bone matrix mineralization in zebrafish and farmed fish. Recently these tools are being applied to the screening of natural extracts (e.g. from seaweeds and microalgae) and compound libraries to discover molecules that could serve as the next generation therapeutics against human pathologies including rare diseases such as the Keutel or the CDKL5 syndromes, and skeletal disorders such as osteoporosis and Paget's Disease of bone.

Atividades

Atividades
2020/01/31 - 2024/01/31. Membro de associação. President of the Portuguese Society of Genetics, elected in January 2020 for 2 year period. Re-elected for a second 2yr term until January 2024. President.
2021/12 - 2022. Comissão de avaliação. A3ES_Convite para participar na avaliação de novos ciclos de estudo na area da Biologia / Biomedicina. A3ES.
2019/01 - 2022/12. Comissão de avaliação. Convite para integrar painel de avaliação dos relatorios finais de projectos da FCT 2019-2022, area da Biologia Experimental e Bioquimica. Fundação para a Ciência e a Tecnologia. Fundação para a Ciência e a Tecnologia.
2022/01 - 2022/07. Comissão de avaliação. A3ES: convite para avaliar novos cursos, área da biotecnologia.
2021/12 - 2022/05. Membro de comissão. procedimento concursal internacional para professor catedrático na Faculdade de Ciências e Tecnologia referência: P053-21-11331, area das ciencias da vida. Edital_1480_2021. Membro. Universidade de Coimbra.
2021/06 - 2022/05. Arbitragem científica em conferência. Meeting of the European Calcified Tissue Society. Helsinquia 2022. ECTS.
2022/02. Júri de grau académico. PhD: Stress granules in Polyglutamine diseases: new targets for therapeutic intervention? . Presidente do júri. Adriana do Vale Marcelo (Doutoramento). Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/11/01 - 2022/02/28. Membro de comissão. Membro da Comissão de avaliação das candidaturas ao curso de medicina da Universidade do Algarve- Avaliação e creditação de formação anterior de + de 100 candidaturas. Membro. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/11/05 - 2022/02/28. Comissão de avaliação. Invitation to participate in evaluation of the proposal(s) submitted in response to the following
call(s) for proposal(s):
- HORIZON-MSCA-2021-PF-01. European Commission. European Commission.
2021/02/12 - 2022/02/10. Membro de comissão. concurso documental internacional, para recrutamento na modalidade de contrato de trabalho em funções públicas por tempo indeterminado, para 1 posto de trabalho e provimento da respetiva vaga na categoria de professor catedrático na área disciplinar de Biomedicina, do mapa de pessoal docente da Universidade da Beira Interior, Edital n.º 192/2021 de 12 de Fev de 2021. Membro. Universidade da Beira Interior.
2021/12 - 2022/02/07. Comissão de avaliação.
21-FWO-PDOC-0556 - Harnessing transcriptome and proteome wide analyses and engineered reporter assays to unravel the immunopathogenesis of 'multisystem inflammatory syndrome in children' (MIS-C).. European Science Foundation. Research Foundation Flanders’ (FWO) .
2021/12 - 2022/01. Comissão de avaliação. Avaliação do relatório de atividades da Prof Associada do departamento de Biologia Animal da FCUL. Universidade de Lisboa, Faculdade de Ciências.
2022/01/24. Júri de grau académico. PhD em Ciências Biomédicas, especialidade de Neurociências, Faculdade Medicina da Universidade de Lisboa, . Arguente principal. Catarina Miranda Lourenço, (Doutoramento). Universidade de Lisboa Faculdade de Medicina.
2022/01/14. Júri de grau académico. Provas de Agregação em ECOLOGIA HUMANA E ADAPTAÇÃO. Arguente principal. Cristina Maria Proença Padez (Agregação). Universidade de Coimbra Faculdade de Ciencias e Tecnologia.
2021/12 - 2022/01/04. Comissão de avaliação. Evaluation of postdoctoral fellowships- PARIS REGION FELLOWSHIP PROGRAMME. Paris Region FP. European Commission Marie Sklodowska-Curie Actions.
2021/12/01 - 2021/12/31. Comissão de avaliação. European Calcified Tissue Society- evaluation of applications for ECTS Academy. European Calcified Tissue Society. European Calcified Tissue Society.
2015/09 - 2021/12/13. Comissão de avaliação. Invitation to be part of the evaluation committee for annual applications for Medalhas l'Oreal. Fundação para a Ciência e a Tecnologia. Fundação L'Oreal.
2021/04 - 2021/10/31. Organização de evento. Organização do Encontro anual de doutorandos da Universidade do Algarve https://www.ualg.pt/en/doctoral-college (2021). Universidade do Algarve.
2021/09. Júri de grau académico. PhD: Development of a high throughput screening strategy for drug discovery: from marine fungi to stem cell application. Arguente principal. Pietro Marchese (Doutoramento). National University of Ireland Galway School of Medicine.
2021/07 - 2021/09. Comissão de avaliação. Participate in peer review of scientific proposals submitted to ERC starting grant 2021 call. European Research Council. European Research Council.
2021/09/21. Apresentação oral de trabalho. Holt Oram syndrome and Thalidomide toxicity: same molecular targets??
. Webinar series_COST action Eurosoftcalcnet. Tamas Aranyi (online, Hungria).
2021/07/30. Júri de grau académico. Provas de Agregação em Biomedicina: Celulas estaminais e terapias celulares. Arguente principal. Liliana Inácio Bernardino (Agregação). Universidade da Beira Interior Faculdade de Ciências da Saúde.
2020/06 - 2021/06. Arbitragem científica em conferência. European Calcified Tissue Society Congress . ECTS.
2021/05/28. Júri de grau académico. Provas de Agregação em Biologia, especialidade de Biologia Celular e Saúde. Arguente principal. Sandra Cristina Almeida Paiva (Agregação). Universidade do Minho Escola de Ciências.
2021 - 2021/04/26. Membro de comissão. Concurso internacional para ocupação de um posto de trabalho da carreira docente universitária, na categoria de Professor Associado, área disciplinar de Ciências da Vida, especialidade de Biofísica, Bioeletrónica e Biosensores da Faculdade de Ciências e Tecnologia da Universidade de Coimbra, cujo edital Edital n.º 273/2021, publicado em Diário da República, 2.ª série, n.º 44, de 04/03.. Membro. Universidade de Coimbra Departamento de Ciências da Vida.
2021/02 - 2021/03. Comissão de avaliação. Invitation to integrate evaluation committee for FWO postdoctoral applications. Research Foundation Flanders’ (FWO) . Research Foundation Flanders’ (FWO) .
2021/01/14. Júri de grau académico. Provas de Agregação em Ciencias Biomédicas- Celulas Estaminais. Vogal. José Eduardo Marques Bragança (Agregação). Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
1986 - 2020. Membro de associação. American Society for Bone and Mineral Research. member.
2020/03/01 - Presente. Orientação. IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS.Biomedical Sciences (Doutoramento). Coorientador.
2019/03/01 - Presente. Orientação. Epigenetic regulation of ZNF687 in bone cells: elucidation of its role in the progression of Paget’s disease towards giant cell tumor of bone.Biomedical Sciences (Doutoramento). Coorientador.
2019/01 - Presente. Orientação. Effect of marine derived extract on osteogenesis and mineralogenesis.Biomedical Sciences (Doutoramento). Coorientador.
2019/01 - Presente. Orientação. Effects of anti- and pro-oxidants in bone mineralization and remodelling.Biomedical Sciences (Doutoramento). Coorientador.
2011/01/01 - 2018/12/31. Comissão de avaliação. European Research Council - Evaluator. LS9 panel. European Research Council. European Research Council.
2015/01/01 - 2018/12/31. Comissão de avaliação. Chair of LS9 panel, ERC. European Research Council. European Research Council.
2012 - 2017. Orientação. "CONTRIBUTION TO THE MOLECULAR CHARACTERIZATION OF OSTEOARTHRITIS AND OSTEOPOROSIS PHENOTYPES ASSOCIATED WITH HEREDITARY HEMOCHROMATOSIS".Ciências Biomédicas (Doutoramento). Orientador.
2017 - Presente. Orientação. Molecular basis for the epigenetic regulation of MGP in cancer.Ciencias Biomédicas (Doutoramento). Coorientador.
2017/10 - Presente. Orientação. How microplastics and adsorbed pollutants affect zebrafish development?.PhD Program in Marine, Earth and Environmental Sciences, (Doutoramento). Coorientador.
2011 - 2016. Orientação. Characterization of bone pathologies in the ins2+/akita mouse, a new model for diabetes insulindependent: contribution for a better understanding of the disease in humans.Ciências Biomédicas (Doutoramento). Orientador.
2013 - 2016/10. Orientação. Characterization of the histological and genetic profile of articular damage in a hemochromatosis mouse model". .Medicina (Doutoramento). Orientador.
2015. Júri de grau académico. DRUG REPURPOSING IN THE TREATMENT OF MELANOMA BRAIN METASTASIS. Vogal. BILLY SAMUEL HILL (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.
2012 - 2015. Orientação. Genetic and functional analysis of the PDB6 locus in Paget´s disease of bone.Ciências Biomédicas (Doutoramento). Orientador.
2010 - 2015. Orientação. Mef2c: Expression, Regulation and Interaction with Target Genes in Health and Diseases.Ciências Biomédicas (Doutoramento). Orientador.
2010 - 2015. Orientação. Molecular Characterization of Gla Rich Protein (GRP) Gene Expression and Function.Ciências Biomédicas (Doutoramento). Orientador.
2009 - 2015. Orientação. IDENTIFICATION OF NOVEL MOLECULAR DETERMINANTS OF TISSUE MINERALIZATION IN FISH.Ciências Biomédicas (Doutoramento). Orientador.
2008 - 2015. Orientação. EVOLUTION, GENE REGULATION AND FUNCTIONAL ANALYSISN OF BMP2 IN FISH.Ciências Biomédicas (Doutoramento). Orientador.
2007 - 2014. Orientação. MOLECULAR STRUCTURE AND FUNCTIONAL ANALYSIS OF RUNX3 IN ZEBRAFISH.Ciências Biomédicas (Doutoramento). Orientador.
2014 - Presente. Membro de associação. European Calcified Tissue Society. member.
2008 - 2012. Orientação. Study of Perkinsus Olseni Infection Mechanisms: Identification and Regulation of Parasite Genes Differentially Expressed in Response to Host and Environmental Stress.Biologia (Doutoramento). Orientador.
2009 - 2012/12. Orientação. Insights into molecular and cellular events involved in human pathological fusion of vertebral joints through the use of zebrafish as model organism.Molecular and Cellular Biology (Doutoramento). Coorientador.
2008 - 2012/05. Orientação. Characterization of metabolic pathways in the protozoan parasite Perkinsus atlanticus/olseni: Identification of potential targets for therapeutic drugs.Bioquimica (Doutoramento). Orientador.
2004/09/01 - 2012/02. Orientação. Abundance, site fidelity and population structure of humpbacks whales (Megaptera novaeangliae) in S. Tomé e Príncipe”.Population Genetics (Doutoramento). Coorientador.
2005/04/01 - 2011/05. Orientação. Role of the transcriptional regulator FHL2 in bone formation: Identification of fish bone-specific target genes and regulatory mechanisms".Bioquimica (Doutoramento). Coorientador.
2005/04 - 2010/07. Orientação. Identification and characterization of a new calcium binding protein from sturgeon, Gla rich protein or GRP. Contribution to unveil its function in vertebrates.BIoquimica (Doutoramento). Coorientador.
2003/09/01 - 2008. Orientação. Effects of vanadate and insulin treatment on proliferation, differentiation and mineralization of two fish bone derived cell lines, Vsa13 e Vsa116.Bioquimica (Doutoramento). Coorientador.
2003 - 2008. Orientação. Identification of P. Atlanticus genes differentially expressed in response to parasite-host interaction and development of an in vivo infestation system.Biologia Molecular (Doutoramento). Coorientador.
1999 - 2006/11. Orientação. Population genetics of an endangered species, the Bonelli’s eagle(Hieraaetus fasciatus).Population genetics (Doutoramento). Coorientador.
2000 - 2005/07. Orientação. “Functional analysis of bone-related Gla proteins from bony fish during skeletal development”..Biologia Molecular (Doutoramento). Orientador.
1998 - 2003/01. Orientação. Matrix Gla protein (MGP) de peixe: abordagem bioquímica e estrutural para o esclarecimento da sua função biológica.Bioqumica (Doutoramento). Orientador.
1998 - 2002/12. Orientação. Controle da expressão genética da proteina da matriz extracelular “matrix Gla protein”: estudos comparativos em anfíbios e peixes.Molecular biology. Orientador.
1995 - 2001. Orientação. Clonagem do gene da proteína BGP (Bone Gla protein) do peixe ósseo Sparus aurata (dourada). Organização molecular, expressão ao longo do desenvolvimento e implicações evolutivas”. .Molecular biology (Doutoramento). Orientador.
1993/01/01 - Presente. Membro de associação. Sociedade Portuguesa de Bioquimica-Member(ongoing). Presidente elect 2005-2008. President of the General Assembly2009-2010. Member.

Projetos

Projetos
2020/03/01 - 2024/04/30. IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS, PhD fellowships. Orientador. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve; Centro de Ciências do Mar.
2018/08/01 - 2023/07/31. Aquaculture meets Biomedicine: Innovation in skeletal health research /BIOMEDAQU, Marie Sklodowska-Curie Actions-Innovative Training Networks. Investigador responsável. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/01/01 - 2023/06/30. MarEmPó, COMPETE2020, CRESC Algarve 2020, PT2020 e FEDER. Investigador. Universidade do Algarve - Campus de Gambelas.
2020/04/01 - 2023/03/31. Understanding the pathophysiology of Keutel Syndrome: A path towards cure, European Joint Program on Rare Diseases (EJP RD). Investigador responsável. Centro de Ciências do Mar; Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2020/01/01 - 2023/01/31. ZEBRABLOOM_Desenvolvimento de produtos comerciais formulados com microalgas para o enriquecimento de presas vivas de peixe-zebra, Projeto de co.promoção. Investigador. Universidade do Algarve.
2018/11/01 - 2022/04/30. KCITAR ALGARVE, PORegional Algarve. Investigador. Universidade do Algarve - Campus de Gambelas.
2019/02/01 - 2021/12/31. Zebrafish as model to analyse CDKL5 function, Orphan Disease Center. Investigador responsável. Centro de Ciências do Mar; Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2018/01/01 - 2021/07/31. Novos compostos marinhos como fonte nutricional para uma melhoria de Qualidade e Bem estar de peixes em aquacultura., MAR2020. Investigador responsável. Universidade do Algarve - Campus de Gambelas.
2018/01/01 - 2021/07/31. BLUE biotechnology as a road for innovation on human health aiming smart growth in Atlantic Area., Transnational Cooperation Programme Atlantic Area (Porto). Investigador responsável. Universidade do Algarve - Campus de Gambelas.
2017/04/01 - 2021/06/30. RED transfronteriza para el desarrollo de productos innovadores con microALGAs, European Commission (Brussels, Spain) INTERREG – POCTEP.. Investigador. Universidade do Algarve.
2017/04/01 - 2021/06/30. Desenvolvimento e implementação de alimentos suplementados em macroalgas ricas em vitamina K no cultivo do Linguado, Mar2020. Investigador. Universidade do Algarve - Campus de Gambelas.
2016/09/01 - 2019/12/31. Insights into Matrix Gla protein (MGP) regulation in colorectal cancer, Prize from Portuguese Society of Gastroenterology. Investigador responsável. Centro de Ciências do Mar.
2016/04/01 - 2019/03/31. Desenvolvimento de uma prémistura de micronutrientes para optimizar as dietas para larvas de peixes marinhos., CRESC Algarve 2020. Investigador. Universidade do Algarve.
2013/10/01 - 2018/09/30. Clinical and molecular heterogeneity of Paget's disease of bone, Canadian Institutes of Health Research (CIHR) Operating grant program. Investigador. Centro de Ciências do Mar.
2012 - 2015. iONE-FP7 project Implantable Organic Nano-Electronics, I-ONE. Investigador.
2012 - 2015. Desenvolvimento de rações optimizados para desenvolvimennto e crescimento do peixe zebra, um modelo com aplicações biomédicas, QREN I&DT – Co-promoção. Investigador. Universidade do Algarve.
2014/11/01 - 2015/12/31. Estudo piloto para melhoramento do status nutricional em vitamina K: optimização da reprodução e demonstração da melhoria na qualidade larvar de linguado, PROMAR. Investigador. Programa Operacional Pesca 2007-2013 (PROMAR).
2012 - 2014. Development of innovating biomedical products from marine resources valorisation., MARMED. Investigador. Universidade do Algarve Departamento de Ciências Biomédicas e Medicina.
2011/06/01 - 2014/05/31. Intelligent Cell Surfaces (ICS), EUROCORES. Outra. Universidade do Algarve.
2009 - 2013. Development and characterization of zebrafish stem cells: implications for transgenesis, FISHCell. Investigador. Centro de Ciências do Mar.
2010 - 2013. Effects of dietary vitamin K supplementation on growth and skeletal development of teleost fish, SpecialK. Outra. Centro de Ciências do Mar.

Produções

2009. "Lab-it Laboratorio Itinerante em Genética Molecular". Registada.
2023. "Effects of marine-derived extracts on osteogenesis and mineralogenesis". Doutoramento.
2023. "EPIGENETIC REGULATION OF ZNF687 IN BONE CELLS: ELUCIDATION OF ITS ROLE IN THE PROGRESSION OF PAGET’S DISEASE TOWARDS GIANT CELL TUMOR OF BONE". Doutoramento.
2023. "IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS". Doutoramento.
Adrião, Andreia; Santana, Isabel; Ribeiro, Carolina; Cancela, M. Leonor; Conceição, Natércia; Grazina, Manuela. 2022. "Identification of a novel mutation in MEF2C gene in an atypical patient with frontotemporal lobar degeneration". Neurological Sciences, 43 (1): 319-326. https://doi.org/10.1007/s10072-021-05269-0
Laizé, Vincent; Rosa, Joana T.; Tarasco, Marco; Cancela, M. Leonor. 2022. "Status, challenges, and perspectives of fish cell culture—Focus on cell lines capable of in vitro mineralization". Em Cellular and Molecular Approaches in Fish Biology, editado por Ignacio, Fernandez; Fernandes, JMO, 381-404. Elsevier. https://doi.org/10.1016/b978-0-12-822273-7.00004-5
2022. "“ANALYSIS OF THE MUTATIONS ASSOCIATED WITH PAGET DISEASE OF BONE IN A SET OF PATIENTS FROM ALENTEJO AND ALGARVE". Mestrado.
2022. "Função da Elastina no desenvolvimento das calcificações ectópicas da cartilagem associadas a uma deficiência em MGP: contribuição para o estudo da sindrome de Keutel". Mestrado.
2022. "Molecular basis for the epigenetic regulation of MGP in cancer". Doutoramento.
2022. "“How microplastics and adsorbed pollutants affect zebrafish development?”,". Doutoramento.
2022. "Effect of Antioxidant and Pro-oxidant on Bone mineralization and Remodelling". Doutoramento.
Poudel, Sunil; Izquierdo M; Leonor Cancela; Gavaia, P. 2022. "Reversal of Doxorubicin-induced bone loss and mineralization by supplementation of Resveratrol and MitoTEMPO in the early development of Sparus aurata. ". Nutrients, 14.
Rotter, Ana; Barbier, Michéle; Bertoni, Francesco; Bones, Atle M.; Cancela, M. Leonor; Carlsson, Jens; Carvalho, Maria F.; et al. 2021. "The Marine Environment, a Treasure Trove for Biotechnology". Frontiers in Marine Science, 8 (629629). https://doi.org/10.3389/fmars.2021.629629
Cancela, M. Leonor; Laizé, Vincent; Conceição, Natércia; Kempf, Hervé; Murshed, Monzur. Autor correspondente: Cancela, M. Leonor. 2021. "Keutel Syndrome, a Review of 50 Years of Literature". Frontiers in Cell and Developmental Biology, 9 (642136). https://doi.org/10.3389/fcell.2021.642136
Varela, Débora; Varela, Tatiana; Conceição, Natércia; Ferreira, Ângela; Marques, Nuno; Silva, Ana Paula; Azevedo, Pedro; et al. Autor correspondente: Cancela, M. Leonor. 2021. "Functional analysis of two novel TBX5 variants present in individuals with Holt Oram syndrome with different clinical manifestations". Molecular Genetics and Genomics, 296 (4): 809-821. https://doi.org/10.1007/s00438-021-01781-2
Varela, Tatiana; Conceição, Natércia; Laizé, Vincent; Cancela, M. Leonor. Autor correspondente: Cancela, M. Leonor. 2021. "Transcriptional regulation of human
DUSP4
gene by cancer-related transcription factors". Journal of Cellular Biochemistry, 122 (10): 1556-1566. https://doi.org/10.1002/jcb.30078
Varela, Débora; Conceição, Natércia; Cancela, M. Leonor. Autor correspondente: Cancela, M. Leonor. 2021. "Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors". Gene, 768. https://doi.org/10.1016/j.gene.2020.145322
Roberto, Vânia P.; Surget, Gwladys; Le Lann, Klervi; Mira, Sara; Tarasco, Marco; Guérard, Fabienne; Poupart, Nathalie; et al. Autor correspondente: Cancela, M. Leonor. 2021. "Antioxidant, Mineralogenic and Osteogenic Activities of Spartina alterniflora and Salicornia fragilis Extracts Rich in Polyphenols". Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.719438
Tarasco, Marco; Gavaia, Paulo J.; Bensimon-Brito, Anabela; Cardeira-da-Silva, João; Ramkumar, Srinath; Cordelières, Fabrice P.; Günther, Stefan; et al. 2021. "New insights into benzo[¿]pyrene osteotoxicity in zebrafish". Ecotoxicology and Environmental Safety, 226. https://doi.org/10.1016/j.ecoenv.2021.112838
Simão, Márcio; Cancela, M. Leonor. 2021. "Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms". Biochemical Society Transactions, 49 (2): 747-759. https://doi.org/10.1042/bst20200672
ML Cancela; Kumar, Navdeep; Carletti, Alessio; Gavaia, P; Muller, Marc; Geurts, Pierre; Marée, Raphael. 2021. "Deep Learning Approaches for Head and Operculum Segmentation in Zebrafish Microscopy Images". Em Computer Analysis of Images and Patterns. Suiça: Springer Nature Switzerland AG.
ML Cancela; Laizé, V; Rosa, Joana. 2021. "Status, challenges, and perspectives of fish cell culture—Focus on cell lines capable of in vitro mineralization". Em Cellular and molecular approaches in fish biology , editado por Fernández, Ignacio; Fernandes, JMO. Elsevier.
Rosa, Joana T.; Laizé, Vincent; Gavaia, Paulo J.; Cancela, M. Leonor. 2021. "Fish Models of Induced Osteoporosis". Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.672424
Kumar, Navdeep; Carletti, Alessio; Gavaia, Paulo J.; Muller, Marc; Cancela, M. Leonor; Geurts, Pierre; Marée, Raphaël. 2021. "Deep Learning Approaches for Head and Operculum Segmentation in Zebrafish Microscopy Images". Em Computer Analysis of Images and Patterns, 154-164. 1ª ed. Vol. 13052. Liege, Bélgica: Springer International Publishing. https://doi.org/10.1007/978-3-030-89128-2_15
Cancela, M Leonor; Conceiçao, Natercia; Varela, Tatiana; Laizé, V. 2021. "A expressão dos transcritos do gene DUSP4 como potencial biomarcador no cancro colorretal. ". UALGORITMO, 3: 25-28.
ML Cancela; Laizé, V; Conceiçao, Natercia; Murshed, Monzur; Kempf, Hervé. 2021. "Keutel Syndrome, a Review of 50 Years of Literature". Em Ectopic Mineralization of Tissues: Mechanisms, Risk Factors, Diseases and Prevention., editado por Murshed, Monzur; Herve Kempf; Svetlana Komarova, 275-283. Frontiers in Cell and Developmental Biology.
2021. "Characterization of 5’ and 3’ UTRs from Bone morphogenetic protein receptor type 1A (Bmpr1A) transcripts under the context of bone metabolism". Mestrado.
2021. "Caracterização de duas linhas de peixe-zebra mutantes para a elastina no estudo da síndrome de Keutel". Mestrado.
Tarasco, Marco; Martins, Gil; Gavaia, Paulo J.; Bebianno, Maria J.; Cancela, M. Leonor; Laizé, Vincent. 2020. "ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts". Zebrafish, 17 (1): 18-26. https://doi.org/10.1089/zeb.2019.1801
Simão, Márcio; Leite, Ricardo B.; Cancela, M. Leonor. 2020. "Expression of four new ferritins from grooved carpet shell clam Ruditapes decussatus challenged with Perkinsus olseni and metals (Cd, Cu and Zn)". Aquatic Toxicology, 229. https://doi.org/10.1016/j.aquatox.2020.105675
Rotter, Ana; Bacu, Ariola; Barbier, Michèle; Bertoni, Francesco; Bones, Atle M.; Cancela, M. Leonor; Carlsson, Jens; et al. 2020. "A New Network for the Advancement of Marine Biotechnology in Europe and Beyond". Frontiers in Marine Science, 7 (278). https://doi.org/10.3389/fmars.2020.00278
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Fernández, I.; Santos, A.; Cancela, M.L.; Laizé, V.; Gavaia, P.J.. 2014. "Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and ¿-glutamyl carboxylation of vitamin K-dependent proteins". Environmental Pollution, 194: 86-95. https://doi.org/10.1016/j.envpol.2014.07.015
Richard, N.; Fernández, I.; Wulff, T.; Hamre, K.; Cancela, L.; Conceição, L.E.C.; Gavaia, P.J.. 2014. "Dietary Supplementation with Vitamin K Affects Transcriptome and Proteome of Senegalese Sole, Improving Larval Performance and Quality". Marine Biotechnology, 16 (5): 522-537. https://doi.org/10.1007/s10126-014-9571-2
Laizé, V.; Gavaia, P.J.; Cancela, M.L.. 2014. "Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities". Drug Discovery Today: Disease Models, 13: 29-37. https://doi.org/10.1016/j.ddmod.2014.08.001
Cavaco, S.; Williamson, M.K.; Rosa, J.; Roberto, V.; Cordeiro, O.; Price, P.A.; Leonor Cancela, M.; Laizé, V.; Simes, D.C.. 2014. "Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase". Fish Physiology and Biochemistry, 40 (3): 731-738. https://doi.org/10.1007/s10695-013-9880-9
Fernández, I.; Tiago, D.M.; Laizé, V.; Leonor Cancela, M.; Gisbert, E.. 2014. "Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: Different gene expression of nuclear receptors and ECM proteins". Journal of Steroid Biochemistry and Molecular Biology, 140: 34-43. https://doi.org/10.1016/j.jsbmb.2013.11.012
Rodrigues, Brigite Sandra Nunes Simões. 2014. "Molecular structure and functional analysis of runx3 in zebrafish". Doutoramento. http://hdl.handle.net/10400.1/6851
Roberto, V.. 2014. "Identification and molecular characterization of bone-related micrornas: functional implications". Doutoramento. http://hdl.handle.net/10400.1/7080
Fazenda, Cindy Vitória. 2014. "Molecular characterization of Gla-rich protein (GRP) gene expression and function". Doutoramento. http://hdl.handle.net/10400.1/6842
Vijayakumar, P.; Laizé, V.; Cardeira, J.; Trindade, M.; Cancela, M.L.. 2013. "Development of an in vitro cell system from zebrafish suitable to study bone cell differentiation and extracellular matrix mineralization". Zebrafish, 10 (4): 500-509. https://doi.org/10.1089/zeb.2012.0833
Mira, S.; Arnaud-Haond, S.; Palma, L.; Cancela, M.L.; Beja, P.. 2013. "Large-scale population genetic structure in Bonelli's Eagle Aquila fasciata". Ibis, 155 (3): 485-498. https://doi.org/10.1111/ibi.12065
Leite, R.B.; Milan, M.; Coppe, A.; Bortoluzzi, S.; dos Anjos, A.; Reinhardt, R.; Saavedra, C.; et al. 2013. "MRNA-Seq and microarray development for the Grooved carpet shell clam, Ruditapes decussatus: A functional approach to unravel host -parasite interaction". BMC Genomics, 14 (1). https://doi.org/10.1186/1471-2164-14-741
Conceição, N.; Viegas, M.; Fidalgo, J.; Cancela, M.L.. 2013. "Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture". Molecular and Cellular Biochemistry, 373 (1-2): 41-51. https://doi.org/10.1007/s11010-012-1473-x
Viegas, C.S.B.; Simes, D.C.; Williamson, M.K.; Cavaco, S.; Laizé, V.; Price, P.A.; Cancela, M.L.. 2013. "Sturgeon osteocalcin shares structural features with matrix Gla protein: Evolutionary relationship and functional implications". Journal of Biological Chemistry, 288 (39): 27801-27811. https://doi.org/10.1074/jbc.M113.450213
Adriao, A.; Conceicao, N.; Gavaia, P. J.; Cancela, M. L.. 2013. "Zebrafish as a model to study craniofacial phenotypes related to human MEF2Cmutations". European Journal of Clinical Investigation, 43: 102-102. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000294&KeyUID=WOS:000317141000294
Silva, I. A. L.; Conceicao, N.; Michou, L.; Cancela, M. L.. 2013. "Genetic variation in pdb6 locus and Paget's disease of bone". European Journal of Clinical Investigation, 43: 81-81. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000235&KeyUID=WOS:000317141000235
Adriao, A.; Conceição, N.; Gavaia, Paulo J.; Cancela, Leonor. 2013. "Zebrafish as a model to study craniofacial phenotypes related to human MEF2Cmutations".
Marques, Cátia Andreia Lourenço. 2013. "Evolution, gene regulation and functional analysis of BMP2 in fish". Doutoramento. http://hdl.handle.net/10400.1/6751
Araujo, N.C.P.; Afonso, R.; Bringela, A.; Cancela, M.L.; Cristiano, M.L.S.; Leite, R.B.. 2013. "Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves". Parasitology International, 62 (6): 575-582. https://doi.org/10.1016/j.parint.2013.06.010
Schnorr, KM; Leonor Cancela; Leite, Ricardo B; Anderson L. 2013. "Polypeptides having cellulose activity and polynucleotides encoding same". Concedida/Emitida.
Conceição, N.; Fazenda, C.; Cancela, M.L.. 2012. "Comparative gene promoter analysis: An in silico strategy to identify candidate regulatory factors for Gla Rich Protein". Journal of Applied Ichthyology, 28 (3): 372-376. https://doi.org/10.1111/j.1439-0426.2012.02001.x
Cardeira, J.; Bensimon-Brito, A.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. 2012. "Lordotic-kyphotic vertebrae develop ectopic cartilage-like tissue in Senegalese sole (Solea senegalensis)". Journal of Applied Ichthyology, 28 (3): 460-463. https://doi.org/10.1111/j.1439-0426.2012.01978.x
Fazenda, C.; Silva, I.A.L.; Cancela, M.L.; Conceição, N.. 2012. "Molecular characterization of two paralog genes encoding Gla-rich protein (Grp) in zebrafish". Journal of Applied Ichthyology, 28 (3): 377-381. https://doi.org/10.1111/j.1439-0426.2012.02004.x
Silva, I.A.L.; Cancela, M.L.; Conceição, N.. 2012. "Molecular cloning and expression analysis of XPD from zebrafish (Danio rerio)". Molecular Biology Reports, 39 (5): 5339-5348. https://doi.org/10.1007/s11033-011-1333-x
Cardeira, J.; Vallés, R.; Dionísio, G.; Estévez, A.; Gisbert, E.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. 2012. "Osteology of the axial and appendicular skeletons of the meagre Argyrosomus regius (Sciaenidae) and early skeletal development at two rearing facilities". Journal of Applied Ichthyology, 28 (3): 464-470. https://doi.org/10.1111/j.1439-0426.2012.01979.x
Bensimon-Brito, A.; Cardeira, J.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2012. "Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation". BMC Developmental Biology, 12. https://doi.org/10.1186/1471-213X-12-28
Dionísio, G.; Campos, C.; Valente, L.M.P.; Conceição, L.E.C.; Cancela, M.L.; Gavaia, P.J.. 2012. "Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis". Journal of Applied Ichthyology, 28 (3): 471-476. https://doi.org/10.1111/j.1439-0426.2012.01996.x
Rafael, M.S.; Laizé, V.; Bensimon-Brito, A.; Leite, R.B.; Schüle, R.; Cancela, M.L.. 2012. "Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata". Cellular and Molecular Life Sciences, 69 (3): 423-434. https://doi.org/10.1007/s00018-011-0754-y
Michou, L.; Conceição, N.; Morissette, J.; Gagnon, E.; Miltenberger-Miltenyi, G.; Siris, E.S.; Brown, J.P.; Cancela, M.L.. 2012. "Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone". Bone, 51 (4): 720-728. https://doi.org/10.1016/j.bone.2012.06.028
Rafael, M.S.; Laizé, V.; Florindo, C.; Ferraresso, S.; Bargelloni, L.; Cancela, M.L.. 2012. "Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts". Biochimie, 94 (5): 1128-1134. https://doi.org/10.1016/j.biochi.2012.01.013
Viegas, M.N.; Dias, J.; Cancela, M.L.; Laizé, V.. 2012. "Polyunsaturated fatty acids regulate cell proliferation, extracellular matrix mineralization and gene expression in a gilthead seabream skeletal cell line". Journal of Applied Ichthyology, 28 (3): 427-432. https://doi.org/10.1111/j.1439-0426.2012.01994.x
Bensimon-Brito, A.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2012. "Vestiges, rudiments and fusion events: The zebrafish caudal fin endoskeleton in an evo-devo perspective". Evolution and Development, 14 (1): 116-127. https://doi.org/10.1111/j.1525-142X.2011.00526.x
Rosa, J. T.; Cancela, M. L.; Laize, V.. 2012. "Identification of novel molecular determinants of tissue mineralization in fish". Febs Journal, 279: 538-539. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000308128602753&KeyUID=WOS:000308128602753
Cancela, M. L.; Conceicao, N.; Laize, V.. 2012. "Gla-rich protein, a new player in tissue calcification? (vol 3, pg 174, 2012)". Advances in Nutrition, 3 (6): 831-831. https://doi.org/10.3945/an.112.002857
Parameswaran, V.; Laizé, V.; Gavaia, P.J.; Leonor Cancela, M.. 2012. "ESSA1 embryonic stem like cells from gilthead seabream: A new tool to study mesenchymal cell lineage differentiation in fish". Differentiation, 84 (3): 240-251. https://doi.org/10.1016/j.diff.2012.07.004
Leonor Cancela, M.; Conceição, N.; Laizé, V.. 2012. "Gla-rich protein, a new player in tissue calcification?". Advances in Nutrition, 3 (2): 174-181. https://doi.org/10.3945/an.111.001685
Eckhard Witten, P.; Leonor Cancela, M.. 2012. "Interdisciplinary approaches in fish skeletal biology". Journal of Applied Ichthyology, 28 (3): 297-299. https://doi.org/10.1111/j.1439-0426.2012.02015.x
Fonseca, Maria Leonor Quintais Cancela da; Fonseca, Luís Daniel Salsinha. 2012. "Spatio-temporal gene expression and evolutionary relationship of seabream betainehomocysteine S-methyltransferases". Mestrado. http://hdl.handle.net/10400.1/10516
Dias, J.; Colen, Rita; Rodrigues, V.; Aragão, C.; Engrola, S.; Viegas, Michel; Laizé, Vincent; Gavaia, Paulo J.; Cancela, Leonor. 2012. "Effect of variable levels of dietary cholesterol and plant sterols on the growth performance and bone metabolism in gilthead seabream (Sparus aurata) juveniles". Em Effect of variable levels of dietary cholesterol and plant sterols on the growth performance and bone metabolism in gilthead seabream (Sparus aurata) juveniles.
Fernández, Ignacio; Cancela, Leonor; Gavaia, Paulo J.. 2012. "Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development.". Em Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development..
Brito, Anabela Ben-Simon. 2012. "Insights into molecular and cellular events involved in normal and pathological vertebral development and fusion using zebrafish as model organism". Doutoramento. http://hdl.handle.net/10400.1/5754
Lisboa, Rodrigo. 2012. "Cytogenetic and histological studies of the brook trout (Salvelinus fontinalis) x arctic charr (Salvelinus alpinus) hybrids". Mestrado. http://hdl.handle.net/10400.1/5733
Carvalho, Inês Costa de. 2012. "Population structure of humpback whales (Megaptera novaeangliae) in west coast of Africa". Mestrado. http://hdl.handle.net/10400.1/12188
Cancela, Leonor; Laizé, Vincent; Conceição, N.; Tiago, Daniel M.; Maia, A. T.; Bensimon-Brito, A.; Gavaia, Paulo J.. 2012. "Matrix Gla protein expression: a complex process involving the use of alternative promoters, multiple splicing events and microRNAs". Em Matrix Gla protein expression: a complex process involving the use of alternative promoters, multiple splicing events and microRNAs.
Fonseca, V.G.; Rosa, J.; Laizé, V.; Gavaia, P.J.; Cancela, M.L.. 2011. "Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream". Gene Expression Patterns, 11 (7): 448-455. https://doi.org/10.1016/j.gep.2011.07.003
Tiago, D.M.; Cancela, M.L.; Laizé, V.. 2011. "Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells". Journal of Bone and Mineral Metabolism, 29 (3): 377-382. https://doi.org/10.1007/s00774-010-0243-7
Milan, Massimo; Coppe, Alessandro; Reinhardt, Richard; Cancela, Leonor M; Leite, Ricardo B; Saavedra, Carlos; Ciofi, Claudio; et al. 2011. "Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring". BMC Genomics, 12 (1). https://doi.org/10.1186/1471-2164-12-234
Sousa, S.; Afonso, N.; Bensimon-Brito, A.; Fonseca, M.; Simões, M.; Leon, J.; Roehl, H.; Cancela, M.L.; Jacinto, A.. 2011. "Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration". Development, 138 (18): 3897-3905. https://doi.org/10.1242/dev.064717
Tiago, D.M.; Laizé, V.; Bargelloni, L.; Ferraresso, S.; Romualdi, C.; Cancela, M.L.. 2011. "Global analysis of gene expression in mineralizing fish vertebra-derived cell lines: New insights into anti-mineralogenic effect of vanadate". BMC Genomics, 12. https://doi.org/10.1186/1471-2164-12-310
Cancela, Maria Leonor; Leite, Ricardo B.. 2011. "Exploring an uncommon host-parasite interaction to unveil the uniqueness of Perkinsus sp as a model organism". Doutoramento. http://hdl.handle.net/10400.1/5704
Dionísio, G.; Cancela, Leonor; Gavaia, Paulo J.. 2011. Effect of dietary vitamin K supplementation on skeletal development of Danio rerio. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Gavaia, Paulo J.; Dionísio, G.; Conceição, L. E. C.; Hamre, K.; Cancela, Leonor. 2011. Effects of phylloquinone on Solea senegalensis skeletogenesis. Em World Aquaculture 2011- Aquaculture for a changing world. June 6-10 2011, Natal convention center, Natal, Brazil..
Cardeira, J.; Mendes, A. C.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2011. "Development of chondroid tissues in lordotic-kyphotic Senegalese sole (Solea senegalensis)". Em Development of chondroid tissues in lordotic-kyphotic Senegalese sole (Solea senegalensis).
Dionísio, G.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor. 2011. Effect of warfarin in zebrafish (Danio rerio) bone formation during caudal fin regeneration. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Gavaia, Paulo J.; Dionísio, G.; Cardeira, J.; Cunha, M. E.; Pousão-Ferreira, P.; Conceição, L. E. C.; Cancela, Leonor. 2011. Skeletal quality in Senegalese sole: characterization of fish resulting from environmental and nutritional trials. Em Workshop Cultivation of soles.
Gavaia, Paulo J.; Nicolau, L.; Cancela, Leonor; Pousão-Ferreira, P.. 2011. Early osteological development and deformities of Diplodus sargus (Linnaeus, 1758) and Diplodus vulgaris (Saint-Hillaire, 1817). Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Valles, E.; Cardeira, J.; Dionísio, G.; Estévez, A.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2011. Early axial and appendicular skeletal development of the meagre (Argyrosomus regius). A comparison of two rearing systems. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Simão, Márcio Alexandre Filipe. 2011. "Identificação e caracterização de duas isoformas da Ferritina da amêijoa R. decussatus e avaliação de algumas das suas propriedades biológicas". Mestrado. http://hdl.handle.net/10400.1/2655
Gavaia, Paulo J.; Dionísio, G.; Campos, C.; Carvalho, A. P.; Conceição, L. E. C.; Cancela, Leonor. 2011. Temperature affects skeletogenesis during Senegalese sole (Solea senegalensis, Kaup) larval development. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Silva, Iris Alexandra Lopes da. 2011. "Molecular cloning and analysis of Xeroderma pigmentosum group-D (xpd) in zebrafish". Mestrado. http://hdl.handle.net/10400.1/2233
Milan, Massimo; Coppe, Alessandro; Reinhardt, Richard; Cancela, Leonor; Leite, Ricardo B.; Saavedra, Carlos; Ciofi, Claudio; et al. 2011. "Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring". https://doi.org/10.1186/1471-2164-12-234
Rafael, M. S.. 2011. "Role of the transcriptional regulator FHL2: identification of fish target genes and regulatory mechanisms". Doutoramento. http://hdl.handle.net/10400.1/3734
Dias, J.; Rodrigues, V.; Colen, Rita; Rosa, Joana; Viegas, M. N.; Cardeira, J.; Cancela, Leonor; Gavaia, Paulo J.; Laizé, Vincent. 2011. Dietary lipid quality regulates bone composition and metabolism in gilthead seabream (Sparus aurata) juveniles. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Gavaia, Paulo J.; Dionísio, G.; Cardeira, J.; Cunha, M. E.; Pousão-Ferreira, P.; Conceição, L. E. C.; Cancela, Leonor. 2011. Skeletal quality in Senegalese sole: characterization of fish resulting from environmental and nutritional trials. Em Workshop Cultivation of soles.
Fazenda, C.; Simões, B.; Kelsh, R.N.; Cancela, M.L.; Conceição, N.. 2010. "Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis". Gene, 450 (1-2): 94-102. https://doi.org/10.1016/j.gene.2009.10.007
Viegas, C.S.B.; Conceiçao, N.; Fazenda, C.; Simes, D.C.; Cancela, M.L.. 2010. "Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon (Acipenser naccarii)". Journal of Applied Ichthyology, 26 (2): 214-218. https://doi.org/10.1111/j.1439-0426.2010.01408.x
Rafael, M.S.; Marques, C.L.; Parameswaran, V.; Cancela, M.L.; Laizé, V.. 2010. "Fish bone-derived cell lines: An alternative in vitro cell system to study bone biology". Journal of Applied Ichthyology, 26 (2): 230-234. https://doi.org/10.1111/j.1439-0426.2010.01411.x
Louro, B.; Passos, A.L.S.; Souche, E.L.; Tsigenopoulos, C.; Beck, A.; Lagnel, J.; Bonhomme, F.; et al. 2010. "Gilthead sea bream (Sparus auratus) and European sea bass (Dicentrarchus labrax) expressed sequence tags: Characterization, tissue-specific expression and gene markers". Marine Genomics, 3 (3-4): 179-191. https://doi.org/10.1016/j.margen.2010.09.005
Cancela, M.L.; Witten, P.E.. 2010. "Advances in skeletal biology by understanding the fish skeleton: A multidisciplinary challenge". Journal of Applied Ichthyology, 26 (2). https://doi.org/10.1111/j.1439-0426.2010.01393.x
Simão, M.F.; Leite, R.B.; Rocha, C.; Cancela, M.L.. 2010. "Changes in bioturbation of iron biogeochemistry and in molecular response of the clam ruditapes decussates upon perkinsus olseni infection". Archives of Environmental Contamination and Toxicology, 59 (3): 433-443. https://doi.org/10.1007/s00244-010-9490-9
Conceição, N.; Cox, C.J.; Simões, B.; Viegas, M.; Cancela, M.L.. 2010. "Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes". Journal of Applied Ichthyology, 26 (2): 245-250. https://doi.org/10.1111/j.1439-0426.2010.01415.x
Rosa, J.; Tiago, D.M.; Dias, J.; Cancela, M.L.; Laizé, V.. 2010. "Serum-specific stimulation of proliferation and mineralization of fish bone-derived cells". Journal of Applied Ichthyology, 26 (2): 251-256. https://doi.org/10.1111/j.1439-0426.2010.01414.x
Bensimon-Brito, A.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2010. "The zebrafish (Danio rerio) caudal complex - a model to study vertebral body fusion". Journal of Applied Ichthyology, 26 (2): 235-238. https://doi.org/10.1111/j.1439-0426.2010.01412.x
Rafael, S. M.; Laize, V.; Schule, R.; Cancela, M. L.. 2010. "Fish as a suitable model to unveil the function of the four and half LIM domains protein 2". Febs Journal, 277: 183-183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278565100642&KeyUID=WOS:000278565100642
Leite, R. B.; Cancela, M. L.. 2010. "Changes at transcriptome level during host-parasite interaction using Perkinsus olseni as a model". Febs Journal, 277: 118-118. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278565100422&KeyUID=WOS:000278565100422
Cardeira, J.; Nicolau, L.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2010. "Early skeletal development of meagre (Argyrosomus regius, Asso 1801)".
Gavaia, Paulo J.; Richard, Nadège; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. 2010. "Evaluation of the skeletal quality in Senegalese sole (Solea Senegalensis, Kaup) reared under intensive vs extensive conditions".
ML Cancela; Bensimon-Brito, Anabela; Gavaia, P; Laizé, V. 2010. "Integrated screening methods for identifying modulators of mineralization, and modulators identified therefrom". Concedida/Emitida.
M Leonor Cancela; Gavaia, P; Bensimon-Brito, Anabela; Laizé, V. 2010. " Identification of compound that affects osteogenesis, involves inducing fin regeneration of ray-finned fish by amputating fish fin, contacting fish with test compound, and determining re-mineralization index of fin regeneration". Estados Unidos. Concedida/Emitida.
Leonor Cancela; Laizé, V; Leite, Ricardo B; Danielsen S; Skov LK. 2010. "New isolated polypeptide having organophosphorous hydrolase activity selected from polypeptide containing amino acid sequence, polypeptide encoded by polynucleotide, variant containing deletion of amino acids, used in nucleic acid construct". Estados Unidos. Concedida/Emitida.
Leonor Cancela; Simes, Dina; S B Viegas, Carla. 2010. "A gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof". Expirada.
Laizé, V.; Tiago, D.M.; Aureliano, M.; Cancela, M.L.. 2009. "New insights into mineralogenic effects of vanadate". Cellular and Molecular Life Sciences, 66 (24): 3831-3836. https://doi.org/10.1007/s00018-009-0137-9
Gavaia, P.J.; Domingues, S.; Engrola, S.; Drake, P.; Sarasquete, C.; Dinis, M.T.; Cancela, M.L.. 2009. "Comparing skeletal development of wild and hatchery-reared Senegalese sole (Solea senegalensis, Kaup 1858): Evaluation in larval and postlarval stages". Aquaculture Research, 40 (14): 1585-1593. https://doi.org/10.1111/j.1365-2109.2009.02258.x
Ascenso, R.M.T.; Leite, R.B.; Afonso, R.; Cancela, M.L.. 2009. "Expression pattern of Perkinsus olseni genes in response to bivalves with different susceptibility to perkinsosis". Journal of Fish Diseases, 32 (7): 633-636. https://doi.org/10.1111/j.1365-2761.2009.01039.x
Viegas, C.S.B.; Cavaco, S.; Neves, P.L.; Ferreira, A.; João, A.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Simes, D.C.. 2009. "Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications". American Journal of Pathology, 175 (6): 2288-2298. https://doi.org/10.2353/ajpath.2009.090474
Roberto, V.P.; Cavaco, S.; Viegas, C.S.B.; Simes, D.C.; Ortiz-Delgado, J.-B.; Sarasquete, M.C.; Gavaia, P.J.; Cancela, M.L.. 2009. "Matrix Gla protein in turbot (Scophthalmus maximus): Gene expression analysis and identification of sites of protein accumulation". Aquaculture, 294 (3-4): 202-211. https://doi.org/10.1016/j.aquaculture.2009.06.020
Gavaia, Paulo J.; Richard, N.; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. 2009. "Skeletal evaluation and technical improvements to decrease the incidence of skeletal deformities in Solea senegalensis, Kaup".
Gavaia, Paulo J.; Domingues, S.; Engrola, S.; Drake, P.; Sarasquete, C.; Dinis, Maria Teresa; Cancela, Leonor. 2009. Comparing skeletal development of wild and hatchery-reared Senegalese sole (Solea senegalensis, Kaup 1858): Evaluation in larval and postlarval stages. The Senegalese sole is a marine pleuronectiform that naturally occurs in Southern Europe and Mediterranean region where it is being produced in aquaculture, in particular in Portugal and Spain. The aim of this study was to assess the quality of hatchery-reared larvae in comparison with those reared in the wild, and determine to which extension wild growing larvae are also affected by skeletal defo. https://doi.org/10.1111/j.1365-2109.2009.02258.x
Gavaia, Paulo Jorge; Domingues, Susana; Engrola, Sofia; Drake, Pilar; Sarasquete, Carmen; Dinis, M Teresa; Cancela, M Leonor. 2009. "Comparing skeletal development of wild and hatchery-reared Senegalese sole (Solea senegalensis, Kaup 1858): evaluation in larval and postlarval stages". Aquaculture Research, 40 (14): 1585-1593. https://doi.org/10.1111/j.1365-2109.2009.02258.x
Roberto, V.; Cavaco, S.; Simes, Dina; Gavaia, Paulo J.; Cancela, Leonor. 2009. "Mgp expression and accumulation in heart and kidney of turbot (Scophthalmus maximus)".
Peres dos Santos, R.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor. 2009. "Warfarin effects in the skeletal development of zebrafish (Danio rerio)".
Cardeira da Silva, J.; Dionísio, G.; Bensimon-Brito, A.; Cancela, Leonor; Gavaia, Paulo J.. 2009. "Skeletal development and performance of zebrafish Danio rerio (Hamilton, 1822) larvae and juvenile fish fed with different diets".
Gavaia, Paulo J.; Richard, N.; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. 2009. "Skeletal evaluation and technical improvements to decrease the incidence of skeletal deformities in Solea senegalensis, Kaup".
Santos, Rui Pedro Peres dos. 2009. "O efeito da Varfarina no desenvolvimento esquelético de larvas de peixe zebra (Danio rerio)". Mestrado. http://hdl.handle.net/10400.1/11039
Roberto, V.; Cavaco, S.; Viegas, C. S. B.; Simes, Dina; Ortiz-Delgado, J. B.; Sarasquete, C.; Gavaia, Paulo J.; Cancela, Leonor. 2009. "Matrix gla protein in turbot (Scophthalmus maximus): gene expression analysis and identification of sites of protein accumulation". https://doi.org/10.1016/j.aquaculture.2009.06.020
Silva, João Pedro Gonçalves Cardeira da. 2009. "O efeito da dieta na sobrevivência e no desenvolvimento esquelético e digestivo de larvas e juvenis de peixe-zebra Danio rerio (Hamilton, 1822)". Mestrado. http://hdl.handle.net/10400.1/672
Marques, C. L.; Rafael, M. S.; Tiago, Daniel M.; Cancela, Leonor; Laizé, Vincent. 2009. "Desenvolvimento de sistemas celulares de peixe adequados ao estudo da mineralização in vitro". CanalBQ, 15-20. http://hdl.handle.net/10400.1/4289
Fonseca, P.J.; Serrão, E.A.; Pina-Martins, F.; Silva, P.; Mira, S.; Quartau, J.A.; Paulo, O.S.; Cancela, L.. 2008. "The evolution of Cicada songs contrasted with the relationships inferred from mitochondrial DNA (Insecta, hemiptera)". Bioacoustics, 18 (1): 17-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-52949136924&partnerID=MN8TOARS
Leite, R.B.; Brito, A.B.; Cancela, M.L.. 2008. "An Oxygen Molecular Sensor, the HIF Prolyl 4-Hydroxylase, in the Marine Protist Perkinsus olseni". Protist, 159 (3): 355-368. https://doi.org/10.1016/j.protis.2008.03.002
Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Cancela, M.L.. 2008. "Effect of the herbicide Roundup® on Perkinsus olseni in vitro proliferation and in vivo survival when infecting a permissive host, the clam Ruditapes decussatus". Bulletin of Environmental Contamination and Toxicology, 80 (6): 512-515. https://doi.org/10.1007/s00128-008-9412-y
Viegas, C.S.B.; Simes, D.C.; Laizé, V.; Williamson, M.K.; Price, P.A.; Cancela, M.L.. 2008. "Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates". Journal of Biological Chemistry, 283 (52): 36655-36664. https://doi.org/10.1074/jbc.M802761200
Tiago, D.M.; Laizé, V.; Cancela, M.L.; Aureliano, M.. 2008. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". Cell Biology and Toxicology, 24 (3): 253-263. https://doi.org/10.1007/s10565-007-9034-x
Tiago, D.M.; Laizé, V.; Cancela, M.L.. 2008. "Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development". General and Comparative Endocrinology, 157 (2): 107-115. https://doi.org/10.1016/j.ygcen.2008.04.006
Tanguy, A.; Bierne, N.; Saavedra, C.; Pina, B.; Bachère, E.; Kube, M.; Bazin, E.; et al. 2008. "Increasing genomic information in bivalves through new EST collections in four species: Development of new genetic markers for environmental studies and genome evolution". Gene, 408 (1-2): 27-36. https://doi.org/10.1016/j.gene.2007.10.021
Coesel, S.N.; Baumgartner, A.C.; Teles, L.M.; Ramos, A.A.; Henriques, N.M.; Cancela, L.; Varela, J.C.S.. 2008. "Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress". Marine Biotechnology, 10 (5): 602-611. https://doi.org/10.1007/s10126-008-9100-2
Conceição, N.; Laizé, V.; Simões, B.; Pombinho, A.R.; Cancela, M.L.. 2008. "Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata". Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1779 (1): 28-39. https://doi.org/10.1016/j.bbagrm.2007.11.003
Tiago, D.M.; Cancela, M.L.; Aureliano, M.; Laizé, V.. 2008. "Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line". FEBS Letters, 582 (9): 1381-1385. https://doi.org/10.1016/j.febslet.2008.03.025
Fonseca, Maria Leonor Quintais Cancela da; Vasta, Gerardo; Ascenso, Rita Margarida Teixeira. 2008. "Study of Perkinsus olseni infection mechanisms: identification and regulation of parasite genes differentially expressed in response to host and environmental stress". Doutoramento. http://hdl.handle.net/10400.1/301
Fonseca, Maria Leonor Quintais Cancela da; Gama, Francisco Miguel Portela da; Afonso, Ricardo. 2008. "Estudos sobre aproveitamento biotecnológico da quitina produzida por organismos marinhos". Mestrado. http://hdl.handle.net/10400.1/710
Dionísio, G.; Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2008. "Diets affect skeletal development in zebrafish (Danio rerio)".
Cardeira da Silva, J.; Gavaia, Paulo J.; Brito, A. B.; Cancela, Leonor. 2008. "The use of enhanced green fluorescent protein to track matrix Gla protein expression during zebrafish (Danio rerio) development".
Peres dos Santos, R.; Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2008. "Developmental effects of warfin in the skeletogenesis of zebrafish (Danio rerio) larvae".
Gavaia, Paulo J.; Cancela, Leonor. 2008. "Fish as a model organism to study skeletal development and associated pathologies".
Rainha, Rita Vanessa Cardoso de Almeida. 2008. "Estudo da variabilidade genética de marcadores moleculares ligados ao gene da MGP e sua aplicação para paternidades em Sparus aurata". Mestrado. http://hdl.handle.net/10400.1/530
Madeira, Céline Rodrigues. 2008. "Contribuição parental do linguado do Senegal, Solea senegalensis (KAUP 1858), em aquacultura". Mestrado. http://hdl.handle.net/10400.1/245
Tiago, Daniel M.. 2008. "Role of insulin and insulin-like peptides in bone formation: identification of bone-specific target genes and regulatory mechanisms, and characterization of the insulin-mimetic effect of vanadium". Doutoramento. http://hdl.handle.net/10400.1/422
Kohli, V.; Robles, V.; Cancela, M.L.; Acker, J.P.; Waskiewicz, A.J.; Elezzabi, A.Y.. 2007. "An alternative method for delivering exogenous material into developing zebrafish embryos". Biotechnology and Bioengineering, 98 (6): 1230-1241. https://doi.org/10.1002/bit.21564
Marques, C.L.; Rafael, M.S.; Cancela, M.L.; Laizé, V.. 2007. "Establishment of primary cell cultures from fish calcified tissues". Cytotechnology, 55 (1): 9-13. https://doi.org/10.1007/s10616-007-9098-8
Fonseca, V.G.; Laizé, V.; Valente, M.S.; Cancela, M.L.. 2007. "Identification of an osteopontin-like protein in fish associated with mineral formation". FEBS Journal, 274 (17): 4428-4439. https://doi.org/10.1111/j.1742-4658.2007.05972.x
Robles, V.; Cancela, M.L.. 2007. "Lipid-based transfection as a method for gene delivery in zebrafish (Danio rerio) embryos". Aquaculture Research, 38 (12): 1317-1322. https://doi.org/10.1111/j.1365-2109.2007.01806.x
Rønnestad, I.; Gavaia, P.J.; Viegas, C.S.B.; Verri, T.; Romano, A.; Nilsen, T.O.; Jordal, A.-E.O.; Kamisaka, Y.; Cancela, M.L.. 2007. "Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): Cloning, tissue expression and comparative aspects". Journal of Experimental Biology, 210 (22): 3883-3896. https://doi.org/10.1242/jeb.007898
Robles, V.; Barbosa, V.; Herráez, M.P.; Martínez-Páramo, S.; Cancela, M.L.. 2007. "The antifreeze protein type I (AFP I) increases seabream (Sparus aurata) embryos tolerance to low temperatures". Theriogenology, 68 (2): 284-289. https://doi.org/10.1016/j.theriogenology.2007.05.003
Abreu, Maria Manuela Silva Nunes Reis; Santos, Maria Cristina Amaral Penas Nabais dos; Fonseca, Maria Leonor Quintais Cancela da; Santos, Erika Silva. 2007. "Potencial de utilização de Cistus ladanifer L. na vegetalização de áreas mineiras". Mestrado. http://hdl.handle.net/10400.1/1798
Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor. 2007. "Gene expression during regeneration of zebrafish (danio rerio) fins: relative expression levels of mineralization – related gla proteins". Em Meeting of European COST B23 Action "Oral Development and Regeneration”oceedings of the .
Marques, C. L.; Rafael, M. S.; Cancela, Leonor; Laizé, Vincent. 2007. "Establishment of primary cell cultures from fish calcified tissues". https://doi.org/10.1007/s10616-007-9098-8
Tiago, Daniel M.; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. 2007. "Vanadate and bone metabolism: effect on proliferation and mineralization of fish bone-derived cells".
Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2007. "Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio". Em Conference Proceedings, 265-306.
Tiago, Daniel M.; Laizé, Vincent; Aureliano, M.; Cancela, Leonor. 2007. "Vanadate effects on bone metabolism: fish cell lines as an alternative to mammalian in vitro systems". Em Vanadium Biochemistry , 1-12. Vol. chapter 14. Kerala, Índia: Research Signpost. http://hdl.handle.net/10400.1/1302
Marques, C. L.; Rafael, M. S.; Cancela, Leonor; Laizé, Vincent. 2007. "Establishment of primary cell cultures from fish calcified tissues". https://doi.org/10.1007/s10616-007-9098-8
Pittman, K.; Rønnestad, I.; Gavaia, Paulo J.; Cancela, Leonor; Guerreiro, P. M.; Ribeiro, Laura; Aragão, C.; et al. 2007. "Fish Larval Research: a tool for sustainable food production and understanding environmental impacts on developing organisms". Trabalho apresentado em Aquaculture Europe,2007, 5-10.
Ortiz-Delgado, J.B.; Simes, D.C.; Viegas, C.S.B.; Schaff, B.J.; Sarasquete, C.; Cancela, M.L.. 2006. "Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: Preferential protein accumulation in skeletal and vascular systems". Histochemistry and Cell Biology, 126 (1): 89-101. https://doi.org/10.1007/s00418-005-0125-6
Gavaia, P.J.; Simes, D.C.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Pinto, J.P.; Kelsh, R.N.; Sarasquete, M.C.; Cancela, M.L.. 2006. "Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): Comparative gene and protein expression during larval development through adulthood". Gene Expression Patterns, 6 (6): 637-652. https://doi.org/10.1016/j.modgep.2005.11.010
Braga, D.; Laizé, V.; Tiago, D.M.; Cancela, M.L.. 2006. "Enhanced DNA transfer into fish bone cells using polyethylenimine". Molecular Biotechnology, 34 (1): 51-54. https://doi.org/10.1385/MB:34:1:51
Simões, B.; Conceição, N.; Viegas, C.S.B.; Pinto, J.P.; Gavaia, P.J.; Hurst, L.D.; Kelsh, R.N.; Cancela, M.L.. 2006. "Identification of a promoter element within the Zebrafish colXa1 gene responsive to Runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2aA2". Calcified Tissue International, 79 (4): 230-244. https://doi.org/10.1007/s00223-006-0111-6
Laizé, V.; Viegas, C.S.B.; Price, P.A.; Cancela, M.L.. 2006. "Identification of an osteocalcin isoform in fish with a large acidic prodomain". Journal of Biological Chemistry, 281 (22): 15037-15043. https://doi.org/10.1074/jbc.M600373200
Rafael, M.S.; Laizé, V.; Cancela, M.L.. 2006. "Identification of Sparus aurata bone morphogenetic protein 2: Molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates". Bone, 39 (6): 1373-1381. https://doi.org/10.1016/j.bone.2006.06.021
Cancela, Maria Leonor; Dias, Pedro Beja; Dias, Paula; Mira, Sara. 2006. "Population genetics of an endangered species: the Bonelli's eagle (Hieraaetus fasciatus)". Doutoramento. http://hdl.handle.net/10400.1/10627
Cancela, Maria Leonor; Gavaia, Paulo; Roberto, Vânia Cristina Palma. 2006. "Gla protein localization and histological characterization of bone stuctures in relevant aquaculture fish". Mestrado. http://hdl.handle.net/10400.1/11026
Laizé, Vincent; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. 2006. "Whole-genome sequence analysis: Evidences for new osteocalcin isoforms in fish and tetrapods". Em Whole-genome sequence analysis: Evidences for new osteocalcin isoforms in fish and tetrapods.
Roberto, V.; Gavaia, Paulo J.; Cancela, Leonor. 2006. "Vertebral deformities and local accumulation of gla proteins in sparus aurata". Em Vertebral deformities and local accumulation of gla proteins in sparus aurata.
Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor. 2006. "Regeneration in Zebrafish (Danio rerio) fins: pattern of expression of mineralization related Gla proteins". Em Regeneration in Zebrafish (Danio rerio) fins: pattern of expression of mineralization¿related Gla proteins, editado por Sociedade Portuguesa de Bioquimica.
Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Verri, T.; Cancela, Leonor. 2006. "PepT1 in a coldwater marine teleost larvae- Atlantic cod: cloning and preliminary studies of expression and phylogeny". Acta Bio Medica. , 77. http://hdl.handle.net/10400.1/4498
Gavaia, Paulo J.; Cancela, Leonor. 2006. Skeletal development and bone-related gene expression in fish larvae. The fish skeleton; skeletal malformations; skeletal malformations in mediterranean species; Types of skeletal malformations; Senegal sole skeletal development; Senegal sole skeletal deformities; Skeletal development in Danio rerio; ALP and TRAP in skeletal development; Skeletal development in Pagrus auriga; Time course of skeletal development in Pagrus auriga; Spatio-temporal pattern of bgp expres. http://hdl.handle.net/10400.1/4397
Engrola, S.; Conceição, L.E.C.; Gavaia, P.J.; Cancela, M.L.; Dinis, M.T.. 2005. "Effects of pre-weaning feeding frequency on growth, survival, and deformation of Senegalese sole, Solea senegalensis (Kaup, 1858)". Israeli Journal of Aquaculture - Bamidgeh, 57 (1): 10-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344396118&partnerID=MN8TOARS
Laizé, V.; Pombinho, A.R.; Cancela, M.L.. 2005. "Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: Evidence for more than one osteonectin in Salmonidae". Biochimie, 87 (5): 411-420. https://doi.org/10.1016/j.biochi.2005.01.008
Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Nunes, P.A.; Cancela, M.L.. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". Aquaculture, 243 (1-4): 9-17. https://doi.org/10.1016/j.aquaculture.2004.09.038
Laizé, V.; Martel, P.; Viegas, C.S.B.; Price, P.A.; Cancela, M.L.. 2005. "Evolution of matrix and bone ¿-carboxyglutamic acid proteins in vertebrates". Journal of Biological Chemistry, 280 (29): 26659-26668. https://doi.org/10.1074/jbc.M500257200
Pinto, J.P.; Conceição, N.M.; Viegas, C.S.B.; Leite, R.B.; Hurst, L.D.; Kelsh, R.N.; Cancela, M.L.. 2005. "Identification of a new pebp2aA2 isoform from Zebrafish runx2 capable of inducing osteocalcin gene expression in vitro". Journal of Bone and Mineral Research, 20 (8): 1440-1453. https://doi.org/10.1359/JBMR.050318
Fonseca, V.G.; Lago-Lestón, A.; Laizé, V.; Cancela, M.L.. 2005. "Rapid identification of differentially expressed genes by in situ screening of bacteria". Molecular Biotechnology, 30 (2): 163-165. https://doi.org/10.1385/MB:30:2:163
Elandalloussi, L.M.; Rodrigues, P.M.; Afonso, R.; Leite, R.B.; Nunes, P.A.; Cancela, M.L.. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". Molecular and Biochemical Parasitology, 142 (1): 106-109. https://doi.org/10.1016/j.molbiopara.2005.03.014
Frazão, C.; Simes, D.C.; Coelho, R.; Alves, D.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Carrondo, M.A.. 2005. "Structural evidence of a fourth Gla residue in fish osteocalcin: Biological implications". Biochemistry, 44 (4): 1234-1242. https://doi.org/10.1021/bi048336z
Conceição, N.; Silva, A.C.; Fidalgo, J.; Belo, J.A.; Cancela, M.L.. 2005. "Identification of alternative promoter usage for the matrix Gla protein gene: Evidence for differential expression during early development in Xenopus laevis". FEBS Journal, 272 (6): 1501-1510. https://doi.org/10.1111/j.1742-4658.2005.04590.x
Mira, S.; Wolff, K.; Cancela, M.L.. 2005. "Isolation and characterization of microsatellite markers in Bonelli's eagle (Hieraaetus fasciatus)". Molecular Ecology Notes, 5 (3): 493-495. https://doi.org/10.1111/j.1471-8286.2005.00967.x
Ortiz-Delgado, J.B.; Simes, D.C.; Gavaia, P.; Sarasquete, C.; Cancela, M.L.. 2005. "Osteocalcin and matrix GLA protein in developing teleost teeth: Identification of sites of mRNA and protein accumulation at single cell resolution". Histochemistry and Cell Biology, 124 (2): 123-130. https://doi.org/10.1007/s00418-005-0015-y
Elworthy, S.; Pinto, J.P.; Pettifer, A.; Cancela, M.L.; Kelsh, R.N.. 2005. "Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent". Mechanisms of Development, 122 (5): 659-669. https://doi.org/10.1016/j.mod.2004.12.008
Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. 2005. Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858). Despite much interest in the production of Senegalese sole (Solea senegalensis) in southern Europe, weaning of this species onto artificial diets is problematic and varying results are obtained. The aim of this study was to test two feeding frequencies during a 13-day pre-weaning period and assess their impact on the growth and survival of Senegalese sole. Postlarvae were fed Artemia metanauplii w. http://hdl.handle.net/10400.1/4483
Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. 2005. Effects of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858). Despite much interest in the production of Senegalese sole (Solea senegalensis) in southern Europe, weaning of this species onto artificial diets is problematic and varying results are obtained. The aim of this study was to test two feeding frequencies during a 13-day pre-weaning period and assess their impact on the growth and survival of Senegalese sole. Postlarvae were fed Artemia metanauplii w. http://hdl.handle.net/10400.1/4416
Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. 2005. "Effects of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858)". http://hdl.handle.net/10400.1/4416
Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. 2005. "Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858)". http://hdl.handle.net/10400.1/4483
Cancela, Leonor; Laizé, Vincent; Simes, Dina; Gavaia, Paulo J.; Conceição, N.; Viegas, C. S. B.; Pombinho, A. R.; et al. 2005. "Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution".
Ortiz-Delgado, J. B.; Simes, Dina; Gavaia, Paulo J.; Sarasquete, C.; Cancela, Leonor. 2005. "Osteocalcin and Matrix Gla Protein in developing teleost teeth. Identification of sites of mRNA and protein accumulation at single cell resolution". https://doi.org/10.1007/s00418-005-0015-y
Mariani, Valentina; Viegas, C. A.; Gavaia, Paulo J.; Cancela, Leonor; Giuffra, Elisabetta. 2005. "Comparative analysis of gene expression profiles among distantly related fish species. Insight into skeletal and immunological systems".
Elworthy, S.; P Pinto, Jorge; Pettifer, A.; Leonor Cancela, M.; Kelsh, R. N.. 2005. "Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent". https://doi.org/10.1016/j.mod.2004.12.008
Laizé, Vincent; Pombinho, A. R.; Cancela, Leonor. 2005. "Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: Evidence for more than one osteonectin in Salmonidae". https://doi.org/10.1016/j.biochi.2005.01.008
Laizé, Vincent; Martel, Paulo; Viegas, Carla; Price, P. A.; Cancela, Leonor. 2005. "Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates". https://doi.org/10.1074/jbc.M500257200
Fonseca, V. G.; Lago-Lestón, A.; Laizé, Vincent; Cancela, Leonor. 2005. "Rapid identification of differentially expressed genes by in situ screening of bacteria". https://doi.org/10.1385/MB:30:2:163
Cancela, Leonor; Laizé, Vincent; Simes, Dina; Gavaia, Paulo J.; Conceição, N.; Viegas, C. S. B.; Pombinho, A. R.; et al. 2005. "Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution".
Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. 2005. "Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858)". http://hdl.handle.net/10400.1/4483
Elandalloussi, L. M.; Rodrigues, Pedro; Afonso, R.; Leite, R. B.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". https://doi.org/10.1016/j.molbiopara.2005.03.014
Gavaia, Paulo J.. 2005. "Functional analysis of bone related Gla proteins from bony fish during skeletal development". Doutoramento. http://hdl.handle.net/10400.1/7614
Pinto, Jorge; Conceição, Natércia; S B Viegas, Carla; Leite, Ricardo; Hurst, L. D.; Kelsh, R. N.; Leonor Cancela, M.. 2005. "Identification of a new pebp2 alpha A2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro". https://doi.org/10.1359/JBMR.050318
Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. 2005. "Effects of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858)". http://hdl.handle.net/10400.1/4416
Elandalloussi, Laurence M.; Leite, Ricardo B.; Rodrigues, Pedro; Afonso, Ricardo; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". https://doi.org/10.1016/j.aquaculture.2004.09.038
Elandalloussi, Laurence M.; Rodrigues, Pedro; Afonso, Ricardo; Leite, Ricardo B.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". https://doi.org/10.1016/j.molbiopara.2005.03.014
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Cancela, M.L.; Williamson, M.K.; Price, P.A.. 1994. "The putative RGD-dependent cell adhesion activity of matrix Gla protein is due to higher molecular weight contaminants". Journal of Biological Chemistry, 269 (16): 12185-12189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028233411&partnerID=MN8TOARS
Rannels, S.R.; Cancela, M.L.; Wolpert, E.B.; Price, P.A.. 1993. "Matrix Gla protein mRNA expression in cultured type II pneumocytes". American Journal of Physiology - Lung Cellular and Molecular Physiology, 265 (3 9-3). http://www.scopus.com/inward/record.url?eid=2-s2.0-0027453375&partnerID=MN8TOARS
Cancela, M.L.; Williamson, M.K.; Price, P.A.. 1993. "Retinoic acid increases matrix gla protein in rat plasma". Nutrition Research, 13 (1): 87-91. https://doi.org/10.1016/S0271-5317(05)80659-1
Cancela, M.L.; Price, P.A.. 1992. "Retinoic acid induces matrix gla protein gene expression in human cells". Endocrinology, 130 (1): 102-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026553049&partnerID=MN8TOARS
Cancela, L.; Ishida, H.; Bishop, J.E.; Norman, A.W.. 1992. "Local chromatin changes accompany the expression of the calbindin-D28K gene: Tissue specificity and effect of vitamin D activation". Molecular Endocrinology, 6 (3): 468-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026525323&partnerID=MN8TOARS
Cancela, L.; Hsieh, C.-L.; Francke, U.; Price, P.A.. 1990. "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". Journal of Biological Chemistry, 265 (25): 15040-15048. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025029949&partnerID=MN8TOARS
Cancela, L.; Theofan, G.; Norman, A.W.. 1988. Chapter 15 The pleiotropic vitamin D hormone. Editado por BA Cooke, RJB King, HJ Van der Molen. Vol. 18. New York, Estados Unidos: Elsevier Science Publishers B.V. https://doi.org/10.1016/S0167-7306(08)60650-X
PARISI, M; CANCELA, L. 1988. "TIME COURSE STUDIES ON PHOSPHATE TRANSFER IN FROG URINARY-BLADDER". Kidney International, 33 (1): 58-63. https://doi.org/10.1038/ki.1988.9
Parisi, M.; Cancela, L.. 1988. "Time course studies on phosphate transfer in frog urinary bladder". Kidney International, 33 (1): 58-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023830190&partnerID=MN8TOARS
Cancela, L.; Nemere, I.; Norman, A.W.. 1988. "1a,25 (OH)2 vitamin D3: A steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms". Journal of Steroid Biochemistry, 30 (1-6): 33-39. https://doi.org/10.1016/0022-4731(88)90073-8
De Vernejoul, M.C.; Benamout, M.P.; Cancela, L.; Miravet, L.; Kuntz, D.; Gueris, J.; Gardin, J.P.. 1988. "Primary hyperparathyroidism seen in rheumatology. Clinical manifestations and relationship between bone history and biological parameters ". Revue du Rhumatisme et des Maladies Osteo-Articulaires, 55 (7): 489-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024005167&partnerID=MN8TOARS
Minghetti, P.P.; Cancela, L.; Fujisawa, Y.; Theofan, G.; Norman, A.W.. 1988. "Molecular structure of the chicken vitamin D-induced calbindin-D(28K) gene reveals eleven exons, six Ca2+-binding domains, and numerous promoter regulatory elements". Molecular Endocrinology, 2 (4): 355-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023879973&partnerID=MN8TOARS
Rebut-Bonneton, C.; Ly, S.Y.; Cancela, L.. 1988. "Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement". Hormone and Metabolic Research, 20 (6): 339-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023941120&partnerID=MN8TOARS
Cancela, L.; Rebut-Bonneton, C.. 1987. "Regulation of 24-hydroxylase activity in mouse skin fibroblasts by cholecalciferol derivatives, triamcinolone acetonide and a calcium modulating agent, nicardipine". Journal of Steroid Biochemistry, 28 (5): 479-484. https://doi.org/10.1016/0022-4731(87)90505-X
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1987. "Lack of biological activity of vitamin D3-3ß sulfate during lactation in vitamin D-deficient rats". Reproduction Nutrition Developpement, 27 (6): 979-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023502969&partnerID=MN8TOARS
Le Boulch, N.; Cancela, L.; Miravet, L.; Lange, C.. 1986. "Assessment of vitamin D sulphate in human milk using desorption chemical ionization mass spectrometry". Biomedical Mass Spectrometry, 13 (2): 53-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022572865&partnerID=MN8TOARS
Gruson, M.; Cancela, L.; Denne, M.A.; Miravet, L.. 1986. "Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants.". Endocrinologia experimentalis, 20 (2-3): 329-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022759472&partnerID=MN8TOARS
Cancela, L.; Le Boulch, N.; Miravet, L.. 1986. "Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants". Journal of Endocrinology, 110 (1): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022445355&partnerID=MN8TOARS
Marie, P.J.; Cancela, L.; Le Boulch, N.; Miravet, L.. 1986. "Bone changes due to pregnancy and lactation: Influence of vitamin D status". American Journal of Physiology - Endocrinology and Metabolism, 251 (4). http://www.scopus.com/inward/record.url?eid=2-s2.0-0022966994&partnerID=MN8TOARS
Le Boulch, N.; Cancela, L.; Miravet, L.. 1986. "Calcidiol in human milk. The effect of prohormone on vitamin D status of breast fed unsupplemented infants". Endocrinologia Experimentalis, 20 (2-3): 325-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022981264&partnerID=MN8TOARS
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1985. "Vitamin D3 3ß sulfate has less biological activity than free vitamin D3 during pregnancy in rats". Biology of the Neonate, 48 (5): 274-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022271864&partnerID=MN8TOARS
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1985. "Influence of vitamin D on mineral metabolism, hormonal status and bone histology in lactating rats and their pups". Journal of Endocrinology, 105 (3): 303-309. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021848253&partnerID=MN8TOARS
Rebut-Bonneton, C.; Demignon, J.; Cancela, L.; Miravet, L.. 1985. "Effect of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 maternal loads on maternal and fetal vitamin D metabolite levels in the rat". Reproduction Nutrition Developpement, 25 (3): 583-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021870967&partnerID=MN8TOARS
Cancela, L.; Le Boulch, N.; Miravet, L.. 1984. "Action of vitamin D3-3 beta-sulfate during lactation in the rat.". World review of nutrition and dietetics, 43: 153-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021143980&partnerID=MN8TOARS
de Vernejoul, M.C.; Girot, R.; Gueris, J.; Cancela, L.; Bang, S.; Bielakoff, J.; Mautalen, C.; Goldberg, D.; Miravet, L.. 1982. "Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia". Journal of Clinical Endocrinology and Metabolism, 54 (2): 276-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019960606&partnerID=MN8TOARS
Boulch, N.L.; Cancela, L.; Miravet, L.. 1982. "Cholecalciferol sulfate identification in human milk by HPLC". Steroids, 39 (4): 391-398. https://doi.org/10.1016/0039-128X(82)90063-0
 

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